Yes, it will open just fine. There may be some variations on fonts but even these are typically slight. It should open fine and look just like you would expect it to look normally.
Windows machines require a bit more room to display the same text. Thus layout text and/or fields may have to be slightly resized to keep them from clipping the last letter or descenders (letter "tails" that descend below the text base line). This is an easy, one time fix in most cases. You'll also need to check for unintended font substitutions if you use any fonts on the mac that are not also installed on the PC.
Thanks for the hints on "cleaning up" from MAC to PC!