Do you mean that is you choose A from the first list, and B from the second list, you want to go to The First layout, but if you choose C from the first list and B from the second lst, you want it to go to the Second Layout?
If that is the case you have a potential for 8 combinations. You can set a script to Go To Layout Based On Calculation. Have a Case Statement, like:
Field1= A and Field2 = C ; Layout1 ;
Field1= A and Field2 = D ; Layout2 ;
Field1= A and Field2 = E ; Layout3 ;
Field1= A and Field2 = F ; Layout4 ;
Field1= B and Field2 = C ; Layout5 ;
You could set it as a scipt trigger upon modifying Field2 (though I think I'd prefer a 'Go..' button beside it.)