I've been using quickbooks, now the 2009 edition. Meh. I like that it can keep track of "classes" (aka, lines of business, locations, or whatever, which it seems no one else does), and columnar reporting (e.g., quarters, classes, etc.), but I get frustrated by some limitations (like, it won't let me debit or credit certain accounts directly, if the account types don't match up). Databases, though, seem like they offer infinite possibilities to customize it just the way you want it.
Can Filemaker replicate quickbooks?