Are other menu options also greyed out at this time? (If so perhaps you are in the midst of a paused script)
Made any changes in Manage | Security recently?
Set up a custom menu on this layout?
Under the saved finds menu the other "edit saved finds" option is also greyed out, but as far as I can tell, the usual menu items are working as intended. No custom menus.
We've made an additional permission set, and added a new check to the startup script. I kept the startup script from running, but the inability to save finds remains. I heard that locking the tool bar had an effect on being able to save finds, but our toolbar is visible and unlocked on all permission sets except guest.
I am using the admin permission set, which has full access to everything, and still cannot save/edit finds. I was able to before, and actually can currently choose my previously saved finds.
If the Toolbar is hidden and locked, it appears that the Saved Find requests and menu is greyed out.
This is a problem when using custom menu sets. You need to add the default [ Saved Finds ] sub menu to one of your custom menus. Make sure the menu you add it to is available in find mode.