It's theoretically possible to use FileMaker for this, FileMaker could use Import Records | Folder to import references to all the files in a folder--which could be your hard drive. The import could be setup to populate fields with the file name of each such movie file which could then be searched out in order to determine where the file is located.
But the devil will be in the details and I wonder about performance--both in the time needed to inventory the drive and to search the resulting database. You might download a 30 day free trial and run a few tests...
Thanks for the input, Phil. I just got my hands on the trial. I'll start experimenting. I'm a little concerned about performance, as well... But we'll see how it goes!