Each would work. I like No.1. I would have one layout named... say... New Samples... which would be focused on the procedure of submitting a new sample... like ID, tests, date submitted, expected finish... etc.
The second layout named .... Say... Sample Results... which would be focused just on result entry and analysis....
I forgot to mention, the only way to get to the... Sample Results is to pick from a list of pending Sample No. ... like AA2345435. Use a field to distinguish... pending from finished samples.
Would there be more than one analysis result for a given sample? Do the number of results for a given sample vary?
If yes, to either question, you may want that related table for your results so that you can select one sample and see all results for it appear in a portal.