Excel isn't a database program, it's a spreadsheet and that's a significantly different type of application.
There are a number of hurdles to cross here to get your database up and running.
FileMaker 2.1 is even older than the first version I used decades ago (2.5). It's a flat file database. Not only is there only one table to each file, but there is no ability to define relationships between tables or files--repeating field and data lookups were your only options and scripting was very, very basic.
FileMaker 13, on the other hand, is a relational database system, supports multiple tables in a single file and has many more features not even dreamed of in FileMaker 2.1. Be prepared to invest some time learning about all the new features. Much of the system won't even look the same.
It is possible to convert your file to a .FP6 format, then to .FP7 (fileMaker versions 7-11 used this file format) and from .FP7 to .FMP12--the file format used by FileMaker 13. Given the simplicity of FileMaker 2.1, it might actually convert more smoothly than some newer file formats, but you'll have to carefully test your converted files and see.
You may find it simpler to use Export Records to export the data into a tab file and then import that tab file using Import Records | File with the New Table option to pull your data and data into a file without attempting to also reproduce the layouts. You'd then have to recreate the layouts from scratch though so you'll have to decide and you may want to try both approaches.
First, you'll need a trial copy of FileMaker 6 to convert the file to .FP6 file format. There's a download link for that version in the KnowledgeBase article listed at the end of this message.
Then, you use FileMaker 11 to convert to .fp7 format, before you use Filemaker 13 to convert to .fmp12 format.
Here's a download link for a 30 day free trial copy of Filemaker 11 you can use for the first step of the conversion:
I also recommend that you read these two Knowledge Base articles on converting your files:
Converting to .fp7 format: http://help.filemaker.com/app/answers/detail/a_id/750/kw/converting
Converting to .fmp12 format: http://help.filemaker.com/app/answers/detail/a_id/10571/kw/converting
Be prepared to invest some time into testing and updating the converted files as there is a good chance that your converted files may not function perfectly. The KB articles cover many, but not all of the possible issues. Feel free to post back here with any issues you encounter that don't seem to have been covered by the KB articles.
Filemaker Pro 6 used *.fp5 file extension.
Filemaker 2 used *.fm
Filemaker 3 and 4 used *.fm3
Filemaker 5 and 6 used *.fm5
Filemaker 7 - 11 used *.fm7
Just so Karen does not think something is wrong when she get FP5
Thanks for the assist!