You will not be able to use wildcards in a calculation.
You can instead do the other way around and chose to only return the first three characters from the Get ( ApplicationVersion ) that you then do the comparison on.
You do that with the Left function, Left ( text ; numberOfCharacters ).
The Left function returns the number of charactars that you specify from the left of the text string.
Your script will then be...
If [Left ( Get ( ApplicationVersion ); 3) = "Web"]
Goto Layout [QWERTY]
Hope this helps.
You can also use:
If [ PatternCount ( Get ( ApplicationVersion ); 3) ; "Web" ) ]