I seems rather that you have a hardware problem.
Please check first your harddisk with the disk utility and your RAM using the Apple hardware test utility on your Mac OS X Installation CD.
I walked through those tests with Apple tech support and they were all fine. Apple has now said that it is a 3rd party software issue and there is nothing they can do.
To clarify, out of about 120 apps that I use regularly, only 4 are exhibiting the problem. Mission Critical are Filemaker, Timbuktu, and BB Edit, Eye TV also has the problem. Apps and OS have been deleted and reinstalled. Preferences trashed and restarted - nothing works.
One thing that Apple tried had an effect. We created a new user and logged in under the new user. Each app including Filemaker opened once and worked just fine, but when I quit and went back in - the app would crash immediately on opening again.
I think it is a common problem, but I don't think it is hardware. BBEdit folks are having me delete a folder called /Library/InputManagers/SIMBL in the hopes that it will work but so far no go.
Check directory /Library/Logs/CrashReporter . Any hints there?
It was something in the folder SIMBL in the InputManagers folder. It would not let me move or remove the folder but I was eventually able to replace it with an empty folder. I'm not sure what it is or what it is for.
Everything is back to normal now and Filemaker and all apps are working fine.
Thanks to Mark at BareBones software for the diagnosis and fix!