Are these changes, changes to a field name perhaps?
Filemaker 11 takes much longer to update layouts to show the new field name than FileMaker 10.
Do you see the same delays with a new filemaker file if you make the same changes?
There may be damage to your file that FileMaker 10 tolerates but which causes issues for FileMaker 11--you might do the usual tests: Try a compressed copy, try a clone of the file, test a recovered copy...
Best practice is to never use a recovered file going forward, but to replace damaged files with undamaged back up copies whenever possible.