Thank you for your post.
Do you also have FileMaker Pro? If so, do you ever encounter the same problem?
Since you said "sometimes", does it occur on specific records? Random records? How many objects are on the Layout? How many parts (Header, Body, Footer, etc.). Are you saving as current record or records being browsed? Is this being run via a script?
Any other information you can provide may be helpful in narrowing down the possible cause(s).