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The best way to handle different size layouts is to design for the small screen size and then use auto sizing on an object to stretch the layout for the larger screen.
The easies way to get started is to place a small line in the bottom right hand corner of the layout. With the line selected go to the inspector click the position tab, then under auto sizing remove the top and left locks and apply the right and bottom lock. Click on the data tab and put a 1 in the Hide object when field, this will case the line to be invisible.
You can get a more professional look by adjusting auto sizing on different fields so the field will stretch to.