there is no way to have a Layout inside a Layout. The top part could be a button bar, the right par is a made up of tabs. It's possible to use only one layout for everything, but for a beginner, that could be a lot of work.
If a starter solution within FileMaker has an interface you like, start from it and examine it. It's a good way to learn. You may also download the FileMaker Training Series: Basics here http://info2.filemaker.com/GLFTS13Basics_FTS-13-Basics-Registration-Page.html to learn about FileMaker development.