I've got a database with over 100 layouts that all need to use a set of layout guides that are very carefully placed. Every time I re-open the file, (which is hosted) the guides are gone and must be re-created.
I've locked the guides and set them to show across all layouts. That doesn't help.
If best practices tells us that files should not be developed locally, but always hosted somewhere, then it does not make any sense to require that a file be running locally in order for guides to persist.