Thank you for your post.
I am unable to replicate the issue.
In my file, I set up a layout that had the options Rulers, Show Grid, Show Guides, Snap to Guides, and Dynamic Guides. I saved the layout, and then uploaded the file to FileMaker Server 15.0.3. Now, when I open the hosted file, the options are still available.
Perhaps you are trying to make changes to the hosted file? Since the file is already open and hosted by FileMaker Server, those changes are only temporary. Instead, close the hosted file, move the file to your local machine, make the changes, and then upload the file FileMaker Server.