I usually change the indexing of UUID fields to Unicode, but why do you need to do that for all fields ?
Non-text fields are not influenced by a different indexing btw.
In a solution I'm creating, it contains texts from multiple languages.
In order to be safe and not forget to change the indexing language I wanted to have something that can be set for whole database.
Btw, what's will be the best option for multiple languages? Default or Unicode?