Can FileMaker handle it? Should FileMaker handle it?
I'm not sure what the answers are. My primary experience with FileMaker is about 20+ years as an in-house developer of a 125 table, 60 user, 4GB database. I've also done a number of smaller 50 table, 10 user, meg sized databases. FileMaker handles those with no issue at all.
Is there a point when FileMaker becomes an inappropriate tool for the job. Number of users? Table count? Total file size? Number of "transactions" per time period?
What are some of the larger projects you have done and how are they working out? I'm just trying to get a feel for what level of databases FileMaker is being used for nowadays.