Best option is to create layouts that are iPad specific - try to eliminate scrolling in a form view. Create scripts that check the device and then jump to the correct layout.
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Make sure the layout fits entirely on the iPad. If you have a lot of objects and fields on the layout, you could duplicate the layout and divide the contents of the layout between the two copies. You could also use tabs for this, but I prefer creating a separate layout instead since using FM12 in development.