Not sure exactly what's happening here, but can I just check that you have rulers showing when you try to get rid of the guides? Drag the guides back to the ruler and they should disappear without any issues.
Yeah, rulers are showing and I have dragged them back, and right clicked
and removed them and they keep coming back.
Could it have anything to do with the fact I bounce back and forth between
2 dev machines?
Are you saving layout changes after you do it?
It is set to automatically save layout changes.
However, when you say you're bouncing back and forth between two dev machines - how are you accessing the file? Hosted via FMServer, hosted via FMP(A), just opening the file sitting on a fileshare?
The last one is a definite no-no, it leads to corruption.
FM Server is how I am accessing the DB from both machines using FMPA for the dev on the machines