Out of whack? That description is a bit lacking, LOL. A screen shot in layout mode (and then in browse mode) would help. There are only two things I can think of off-hand: 1) some of the objects may be set to auto-size or 2) alignment or indent is set on some of the text. :^)
I moved everything to the right which works a little bit better, but I had everything in the middle on the bottom of the screen. It looks good on one screen all out of alignment in a larger one
I am afraid I only see one image and it is in browse mode. And I cannot tell exactly what you are pointing at which is out of alignment, Mike. Can you copy and paste all of these layout objects ( Edit - Select All ) and paste them into a new file and upload it somewhere so we can look at the objects themselves? If you do not have a website, you can upload your file to any freeware site such as 4shared.com. It doesn't cost anything.
I have never had resolution affect alignment of objects so I am very interested to help you understand this issue. Also, what version of FileMaker are you using (and have all the updaters been applied; v3 if windows and v4 if Mac, I believe). And what is your OS and version please.