Ummm....what is the problem ??
If you are in layout mode, and switch to browse mode the layout changes? Is that it?
If so, look for script triggers...
No, im in layout mode, then on the top left there is a drop down menu to choose different layout. if i choose the layout that i want to edit, it bring me to another layout.
The most likely script trigger to cause this would be one of the ones you can specify for the entire layout in Layout Setup...